Drug interactions
Azilsartan-chlorthalidone + Drospirenone
Severity: Moderate
Azilsartan-chlorthalidone and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, an effect that adds to that of the angiotensin receptor blocker azilsartan. Chlorthalidone tends to lower potassium, so the net effect varies but hyperkalemia is possible in at-risk patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from aldosterone antagonism and angiotensin receptor blockade, partly offset by thiazide-like kaliuresis.
What to do
Measure serum potassium during the first treatment cycle in patients on this combination, especially with renal impairment. Choose a different contraceptive if potassium rises persistently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Drospirenone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Drospirenone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, an effect that adds to that of the angiotensin receptor blocker azilsartan. Chlorthalidone tends to lower potassium, so the net effect varies but hyperkalemia is possible in at-risk patients.
How serious is the interaction between Azilsartan-chlorthalidone and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first treatment cycle in patients on this combination, especially with renal impairment. Choose a different contraceptive if potassium rises persistently.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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