Drug interactions
Azilsartan-chlorthalidone + Enoxaparin
Severity: Moderate
Azilsartan-chlorthalidone and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, and the risk is additive with an ARB. The effect is most relevant in patients with renal impairment or diabetes, and chlorthalidone may partly offset it.
What this interaction means in plain words
Azilsartan-chlorthalidone and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-mediated reduction of aldosterone synthesis adds to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Monitor serum potassium and renal function during prolonged enoxaparin therapy. Treat hyperkalemia if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azilsartan-chlorthalidone and Enoxaparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azilsartan-chlorthalidone
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Enoxaparin?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, and the risk is additive with an ARB. The effect is most relevant in patients with renal impairment or diabetes, and chlorthalidone may partly offset it.
How serious is the interaction between Azilsartan-chlorthalidone and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during prolonged enoxaparin therapy. Treat hyperkalemia if it occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
