Drug interactions
Azilsartan-chlorthalidone + Epoprostenol
Severity: Moderate
Azilsartan-chlorthalidone and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, so combining it with antihypertensives may cause additive hypotension. Dizziness or syncope may result.
What this interaction means in plain words
Azilsartan-chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
Additive vasodilation and blood pressure lowering.
What to do
Monitor blood pressure and symptoms of hypotension, and reduce antihypertensive doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Epoprostenol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator, so combining it with antihypertensives may cause additive hypotension. Dizziness or syncope may result.
How serious is the interaction between Azilsartan-chlorthalidone and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension, and reduce antihypertensive doses if needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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