Drug interactions
Azilsartan-chlorthalidone + Eprosartan
Severity: Major
Azilsartan-chlorthalidone and Eprosartan: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two ARBs gives dual blockade of the same receptor with no proven additional benefit and a higher risk of hypotension, hyperkalemia and renal dysfunction.
What this interaction means in plain words
Azilsartan-chlorthalidone and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade reduces aldosterone effects and glomerular filtration pressure.
What to do
Avoid combining two ARBs and use a single agent. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eprosartan 300mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: angiotensin II receptor blockers; "dual blockade of the reninangiotensinaldosteronesystem (RAAS) through the combined use of ACEinhibitors, angiotensin II receptor blockers or aliskiren") — electronic medicines compendium (UK SmPC)
Other interactions of Azilsartan-chlorthalidone
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Eprosartan?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two ARBs gives dual blockade of the same receptor with no proven additional benefit and a higher risk of hypotension, hyperkalemia and renal dysfunction.
How serious is the interaction between Azilsartan-chlorthalidone and Eprosartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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