Drug interactions
Azilsartan-chlorthalidone + Fludrocortisone
Severity: Moderate
Azilsartan-chlorthalidone and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid action causing potassium loss and sodium retention, which adds to chlorthalidone-induced hypokalemia. It may also oppose the blood pressure lowering effect of the antihypertensive combination.
What this interaction means in plain words
Azilsartan-chlorthalidone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Mineralocorticoid-driven renal potassium wasting and sodium retention add to thiazide-like kaliuresis and counter antihypertensive effect.
What to do
Monitor serum potassium and blood pressure and supplement potassium as needed. Reassess fludrocortisone dose if hypertension or hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Fludrocortisone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid action causing potassium loss and sodium retention, which adds to chlorthalidone-induced hypokalemia. It may also oppose the blood pressure lowering effect of the antihypertensive combination.
How serious is the interaction between Azilsartan-chlorthalidone and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure and supplement potassium as needed. Reassess fludrocortisone dose if hypertension or hypokalemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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