Drug interactions
Azilsartan-chlorthalidone + Ibuprofen
Severity: Moderate
Azilsartan-chlorthalidone and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can blunt the blood pressure lowering effect of azilsartan and chlorthalidone. In combination with an ARB and a diuretic, NSAIDs also raise the risk of acute kidney injury, especially in older or volume-depleted patients, and may alter potassium.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, causing sodium and water retention and reduced glomerular perfusion when angiotensin II blockade and diuresis are present.
What to do
Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly at the start of therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ibuprofen?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can blunt the blood pressure lowering effect of azilsartan and chlorthalidone. In combination with an ARB and a diuretic, NSAIDs also raise the risk of acute kidney injury, especially in older or volume-depleted patients, and may alter potassium.
How serious is the interaction between Azilsartan-chlorthalidone and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, particularly at the start of therapy.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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