Drug interactions
Azilsartan-chlorthalidone + Insulin glulisine
Severity: Moderate
Azilsartan-chlorthalidone and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azilsartan may enhance insulin sensitivity and increase hypoglycemia risk, whereas chlorthalidone can worsen glucose control. The net effect on glycemia is unpredictable in patients on insulin.
What this interaction means in plain words
Azilsartan-chlorthalidone and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
ARBs may improve insulin sensitivity while thiazide-like diuretics impair glucose tolerance, partly through potassium depletion.
What to do
Monitor blood glucose closely after starting or changing the antihypertensive and adjust insulin dose accordingly. Check potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Insulin glulisine?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azilsartan may enhance insulin sensitivity and increase hypoglycemia risk, whereas chlorthalidone can worsen glucose control. The net effect on glycemia is unpredictable in patients on insulin.
How serious is the interaction between Azilsartan-chlorthalidone and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting or changing the antihypertensive and adjust insulin dose accordingly. Check potassium periodically.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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