Drug interactions
Azilsartan-chlorthalidone + Lofexidine
Severity: Moderate
Azilsartan-chlorthalidone and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers heart rate and blood pressure, and azilsartan and chlorthalidone also lower blood pressure. Together they can cause excessive hypotension, bradycardia and syncope, particularly during opioid withdrawal treatment.
What this interaction means in plain words
Azilsartan-chlorthalidone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering through central alpha-2 agonism, angiotensin receptor blockade and diuresis-related volume depletion.
What to do
Monitor blood pressure and pulse before doses and during therapy, and hold or reduce lofexidine or antihypertensives if symptomatic hypotension or bradycardia occurs. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Lofexidine?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers heart rate and blood pressure, and azilsartan and chlorthalidone also lower blood pressure. Together they can cause excessive hypotension, bradycardia and syncope, particularly during opioid withdrawal treatment.
How serious is the interaction between Azilsartan-chlorthalidone and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse before doses and during therapy, and hold or reduce lofexidine or antihypertensives if symptomatic hypotension or bradycardia occurs. Ensure adequate hydration.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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