Drug interactions
Azilsartan-chlorthalidone + Naproxen
Severity: Major
Azilsartan-chlorthalidone and Naproxen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as naproxen blunt the antihypertensive effect of ARBs and diuretics by reducing renal prostaglandin synthesis and promoting sodium and fluid retention. The triple combination of NSAID, ARB and diuretic raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may also cause hyperkalemia.
What this interaction means in plain words
Azilsartan-chlorthalidone and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation while ARB blocks efferent constriction and the diuretic lowers volume, impairing glomerular filtration and antagonizing blood pressure control.
What to do
Avoid regular NSAID use where possible and use the lowest dose for the shortest time, or choose paracetamol. Monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azilsartan-chlorthalidone
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Naproxen?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as naproxen blunt the antihypertensive effect of ARBs and diuretics by reducing renal prostaglandin synthesis and promoting sodium and fluid retention. The triple combination of NSAID, ARB and diuretic raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may also cause hyperkalemia.
How serious is the interaction between Azilsartan-chlorthalidone and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use the lowest dose for the shortest time, or choose paracetamol. Monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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