Drug interactions
Azilsartan-chlorthalidone + Nateglinide
Severity: Minor
Azilsartan-chlorthalidone and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and reduce the effect of nateglinide. Glycemic control may worsen after the diuretic is started.
What this interaction means in plain words
Azilsartan-chlorthalidone and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Thiazide-induced impairment of insulin secretion and sensitivity opposes the insulin secretagogue effect (pharmacodynamic antagonism).
What to do
Monitor blood glucose after starting chlorthalidone and adjust the nateglinide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Nateglinide?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone can raise blood glucose and reduce the effect of nateglinide. Glycemic control may worsen after the diuretic is started.
How serious is the interaction between Azilsartan-chlorthalidone and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting chlorthalidone and adjust the nateglinide dose if control worsens.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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