Drug interactions
Azilsartan-chlorthalidone + Patiromer
Severity: Minor
Azilsartan-chlorthalidone and Patiromer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer is a potassium-binding polymer in the gut that can bind some oral drugs. Studies with several drugs showed no clinically important binding, and no separation was required for azilsartan. Patiromer lowers potassium, which may add to chlorthalidone's potassium loss.
What this interaction means in plain words
Azilsartan-chlorthalidone and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Patiromer belongs to Miscellaneous.
Why it happens
Potential binding of cations or drugs in the gut by patiromer; additive potassium lowering with a thiazide-type diuretic.
What to do
Monitor serum potassium and magnesium, as patiromer also lowers magnesium. Separate other oral drugs from patiromer by at least 3 hours as labeled if not tested.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Patiromer?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Patiromer is a potassium-binding polymer in the gut that can bind some oral drugs. Studies with several drugs showed no clinically important binding, and no separation was required for azilsartan. Patiromer lowers potassium, which may add to chlorthalidone's potassium loss.
How serious is the interaction between Azilsartan-chlorthalidone and Patiromer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, as patiromer also lowers magnesium. Separate other oral drugs from patiromer by at least 3 hours as labeled if not tested.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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