Drug interactions
Azilsartan-chlorthalidone + Propranolol
Severity: Minor
Azilsartan-chlorthalidone and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol added to an ARB and thiazide-like diuretic provides additive blood pressure lowering and may cause hypotension or bradycardia. Potassium effects are small and opposing. Propranolol can also mask hypoglycemia, while chlorthalidone may impair glucose tolerance.
What this interaction means in plain words
Azilsartan-chlorthalidone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects with minor opposing effects on serum potassium.
What to do
Monitor blood pressure, heart rate and potassium when starting or adjusting therapy. Monitor glucose in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Propranolol?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol added to an ARB and thiazide-like diuretic provides additive blood pressure lowering and may cause hypotension or bradycardia. Potassium effects are small and opposing. Propranolol can also mask hypoglycemia, while chlorthalidone may impair glucose tolerance.
How serious is the interaction between Azilsartan-chlorthalidone and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when starting or adjusting therapy. Monitor glucose in diabetic patients.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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