Drug interactions
Azilsartan-chlorthalidone + Salmeterol
Severity: Moderate
Azilsartan-chlorthalidone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both chlorthalidone and salmeterol can lower serum potassium, so combined use may cause clinically relevant hypokalemia, particularly with higher beta-agonist doses. Hypokalemia can promote arrhythmias. Azilsartan partly offsets potassium loss.
What this interaction means in plain words
Azilsartan-chlorthalidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from diuretic renal potassium wasting and beta-2 agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium and magnesium, especially at initiation and in patients with severe respiratory disease or heart disease. Correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Salmeterol?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both chlorthalidone and salmeterol can lower serum potassium, so combined use may cause clinically relevant hypokalemia, particularly with higher beta-agonist doses. Hypokalemia can promote arrhythmias. Azilsartan partly offsets potassium loss.
How serious is the interaction between Azilsartan-chlorthalidone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially at initiation and in patients with severe respiratory disease or heart disease. Correct deficits promptly.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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