Drug interactions
Azilsartan-chlorthalidone + Spironolactone
Severity: Moderate
Azilsartan-chlorthalidone and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone and azilsartan both promote potassium retention, raising hyperkalemia risk, particularly in renal impairment, diabetes or older patients. Chlorthalidone offsets this partially, but net potassium remains unpredictable.
What this interaction means in plain words
Azilsartan-chlorthalidone and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Aldosterone receptor antagonism plus angiotensin receptor blockade causes potassium retention, opposed by thiazide-like kaliuresis.
What to do
Check potassium and creatinine at baseline, within the first one to two weeks, and periodically thereafter. Reduce or stop spironolactone if hyperkalemia or worsening renal function occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Spironolactone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Spironolactone and azilsartan both promote potassium retention, raising hyperkalemia risk, particularly in renal impairment, diabetes or older patients. Chlorthalidone offsets this partially, but net potassium remains unpredictable.
How serious is the interaction between Azilsartan-chlorthalidone and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline, within the first one to two weeks, and periodically thereafter. Reduce or stop spironolactone if hyperkalemia or worsening renal function occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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