Drug interactions
Azilsartan-chlorthalidone + Tadalafil
Severity: Moderate
Azilsartan-chlorthalidone and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator and adds to the blood pressure lowering of azilsartan and chlorthalidone. This may cause symptomatic hypotension, dizziness or syncope, particularly at initiation or in volume-depleted patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation via PDE5 inhibition combined with angiotensin receptor blockade and diuretic-induced volume reduction.
What to do
Start tadalafil at a low dose and monitor blood pressure, advising patients to rise slowly. Correct volume depletion before initiating.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Tadalafil?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator and adds to the blood pressure lowering of azilsartan and chlorthalidone. This may cause symptomatic hypotension, dizziness or syncope, particularly at initiation or in volume-depleted patients.
How serious is the interaction between Azilsartan-chlorthalidone and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and monitor blood pressure, advising patients to rise slowly. Correct volume depletion before initiating.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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