Drug interactions
Azilsartan-chlorthalidone + Timolol
Severity: Minor
Azilsartan-chlorthalidone and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol adds to the blood pressure lowering of azilsartan and chlorthalidone and may cause hypotension or bradycardia. Potassium effects are minor and opposing. Absorption from eye drops can be enough to produce systemic effects in some patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects with minor opposing effects on potassium.
What to do
Monitor blood pressure and heart rate, particularly after starting timolol. Check potassium periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Timolol?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic timolol adds to the blood pressure lowering of azilsartan and chlorthalidone and may cause hypotension or bradycardia. Potassium effects are minor and opposing. Absorption from eye drops can be enough to produce systemic effects in some patients.
How serious is the interaction between Azilsartan-chlorthalidone and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly after starting timolol. Check potassium periodically.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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