Drug interactions
Azilsartan-chlorthalidone + Tolvaptan
Severity: Moderate
Azilsartan-chlorthalidone and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan causes aquaresis and combined with a diuretic may produce excessive volume depletion, hypotension and rapid shifts in sodium. Electrolyte and renal changes can occur, including hypernatremia and altered potassium.
What this interaction means in plain words
Azilsartan-chlorthalidone and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Additive diuretic and volume-depleting effects from vasopressin V2 antagonism and thiazide-like diuresis, with ARB-related effects on renal hemodynamics and potassium.
What to do
Monitor serum sodium, potassium, creatinine, blood pressure and volume status closely, especially at initiation. Reduce diuretic doses if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Tolvaptan?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan causes aquaresis and combined with a diuretic may produce excessive volume depletion, hypotension and rapid shifts in sodium. Electrolyte and renal changes can occur, including hypernatremia and altered potassium.
How serious is the interaction between Azilsartan-chlorthalidone and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, creatinine, blood pressure and volume status closely, especially at initiation. Reduce diuretic doses if volume depletion develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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