Drug interactions
Azilsartan-chlorthalidone + Tretinoin
Severity: Minor
Azilsartan-chlorthalidone and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a sulfonamide-type thiazide-like diuretic that can cause photosensitivity, and tretinoin (particularly topical) increases skin sensitivity to light. Together they may increase sunburn or phototoxic reactions, although the effect is generally modest.
What this interaction means in plain words
Azilsartan-chlorthalidone and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects on the skin; the interaction is largely theoretical.
What to do
Advise sun protection with broad-spectrum sunscreen and protective clothing, and reduce sun exposure while both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Tretinoin?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone is a sulfonamide-type thiazide-like diuretic that can cause photosensitivity, and tretinoin (particularly topical) increases skin sensitivity to light. Together they may increase sunburn or phototoxic reactions, although the effect is generally modest.
How serious is the interaction between Azilsartan-chlorthalidone and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun protection with broad-spectrum sunscreen and protective clothing, and reduce sun exposure while both are used.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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