Drug interactions
Azithromycin + Berotralstat
Severity: Moderate
Azithromycin and Berotralstat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin may inhibit P-glycoprotein and raise berotralstat concentrations. Higher berotralstat exposure increases the risk of gastrointestinal effects and QT prolongation.
What this interaction means in plain words
Azithromycin and Berotralstat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Berotralstat belongs to Miscellaneous.
Why it happens
Inhibition of P-glycoprotein efflux of berotralstat by azithromycin.
What to do
Monitor for gastrointestinal adverse effects and consider an ECG if the patient has other QT risk factors. Review the need for the macrolide if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Azithromycin with Berotralstat?
MediHelp rates the interaction as moderate. Azithromycin and Berotralstat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin may inhibit P-glycoprotein and raise berotralstat concentrations. Higher berotralstat exposure increases the risk of gastrointestinal effects and QT prolongation.
How serious is the interaction between Azithromycin and Berotralstat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and consider an ECG if the patient has other QT risk factors. Review the need for the macrolide if symptoms develop.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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