Drug interactions
Azithromycin + Dabigatran etexilate
Severity: Minor
Azithromycin and Dabigatran etexilate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin is a weak P-glycoprotein inhibitor and may slightly raise dabigatran levels. Observational data suggest a small increase in bleeding events with macrolides, but the effect of azithromycin is generally minor.
What this interaction means in plain words
Azithromycin and Dabigatran etexilate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Dabigatran etexilate belongs to Cardiovascular.
Why it happens
Weak inhibition of P-glycoprotein efflux of dabigatran etexilate.
What to do
No dose change is usually needed. Monitor for bleeding, especially in older patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Dabigatran etexilate?
MediHelp rates the interaction as minor. Azithromycin and Dabigatran etexilate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azithromycin is a weak P-glycoprotein inhibitor and may slightly raise dabigatran levels. Observational data suggest a small increase in bleeding events with macrolides, but the effect of azithromycin is generally minor.
How serious is the interaction between Azithromycin and Dabigatran etexilate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for bleeding, especially in older patients or those with renal impairment.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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