Drug interactions
Azithromycin + Entrectinib
Severity: Moderate
Azithromycin and Entrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and azithromycin adds to this effect. Together they may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Azithromycin and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Entrectinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain an ECG and electrolytes at baseline and during co-treatment. Consider a non-QT-prolonging antibiotic if other risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Azithromycin with Entrectinib?
MediHelp rates the interaction as moderate. Azithromycin and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and azithromycin adds to this effect. Together they may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Azithromycin and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and electrolytes at baseline and during co-treatment. Consider a non-QT-prolonging antibiotic if other risk factors exist.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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