Drug interactions
Azithromycin + Pazopanib
Severity: Moderate
Azithromycin and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so together they may increase the risk of serious arrhythmias. Pazopanib labeling also advises caution with other QT-prolonging agents.
What this interaction means in plain words
Azithromycin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Pazopanib belongs to Oncology.
Why it happens
Additive QTc prolongation through cardiac repolarization effects.
What to do
Check a baseline ECG and electrolytes, correct any deficits and repeat ECG monitoring during therapy. Prefer a non-QT-prolonging antibiotic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Azithromycin with Pazopanib?
MediHelp rates the interaction as moderate. Azithromycin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so together they may increase the risk of serious arrhythmias. Pazopanib labeling also advises caution with other QT-prolonging agents.
How serious is the interaction between Azithromycin and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correct any deficits and repeat ECG monitoring during therapy. Prefer a non-QT-prolonging antibiotic when feasible.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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