Drug interactions
Azithromycin + Pitolisant
Severity: Moderate
Azithromycin and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
What this interaction means in plain words
Azithromycin and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Pitolisant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider an alternative antibiotic in patients with QT risk factors. If combined, correct potassium and magnesium and obtain a baseline and follow-up ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Azithromycin with Pitolisant?
MediHelp rates the interaction as moderate. Azithromycin and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, bradycardia or existing heart disease.
How serious is the interaction between Azithromycin and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors. If combined, correct potassium and magnesium and obtain a baseline and follow-up ECG.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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