Drug interactions
Azithromycin + Selpercatinib
Severity: Moderate
Azithromycin and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and azithromycin adds to this effect. Using both may raise the risk of torsades de pointes.
What this interaction means in plain words
Azithromycin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes, correcting abnormalities promptly. Use an alternative antibiotic if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azithromycin and Selpercatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Azithromycin with Selpercatinib?
MediHelp rates the interaction as moderate. Azithromycin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and azithromycin adds to this effect. Using both may raise the risk of torsades de pointes.
How serious is the interaction between Azithromycin and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting abnormalities promptly. Use an alternative antibiotic if QTc becomes significantly prolonged.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
