Drug interactions
Azithromycin + Sorafenib
Severity: Moderate
Azithromycin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Azithromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization through hERG potassium channel blockade.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor the QTc during combined therapy. Consider a non-QT-prolonging antibiotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Azithromycin with Sorafenib?
MediHelp rates the interaction as moderate. Azithromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Azithromycin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor the QTc during combined therapy. Consider a non-QT-prolonging antibiotic if the QTc becomes markedly prolonged.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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