Drug interactions
Azithromycin + Triptorelin
Severity: Moderate
Azithromycin and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with triptorelin can prolong the QT interval, and azithromycin has comparable effects. Combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Azithromycin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization while azithromycin blocks hERG channels.
What to do
Check a baseline ECG and electrolytes, and monitor the QTc if the antibiotic is needed. Consider a non-QT-prolonging antibiotic in patients with other arrhythmia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Azithromycin with Triptorelin?
MediHelp rates the interaction as moderate. Azithromycin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with triptorelin can prolong the QT interval, and azithromycin has comparable effects. Combined use may raise the risk of torsades de pointes.
How serious is the interaction between Azithromycin and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc if the antibiotic is needed. Consider a non-QT-prolonging antibiotic in patients with other arrhythmia risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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