Drug interactions
Aztreonam + Typhoid vaccine live
Severity: Moderate
Aztreonam and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Aztreonam is active against gram-negative bacilli including Salmonella and could reduce vaccine viability and immune response.
What this interaction means in plain words
Aztreonam and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may inhibit the live attenuated Salmonella strain, reducing immunogenicity.
What to do
Give live oral typhoid vaccine at least 3 days after the last aztreonam dose, or vaccinate beforehand. Use the inactivated Vi vaccine if timing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aztreonam
Frequently asked questions
Can I take Aztreonam with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Aztreonam and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Aztreonam is active against gram-negative bacilli including Salmonella and could reduce vaccine viability and immune response.
How serious is the interaction between Aztreonam and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last aztreonam dose, or vaccinate beforehand. Use the inactivated Vi vaccine if timing cannot be separated.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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