Drug interactions
Amoxicillin-clavulanic acid + Aztreonam
Severity: Minor
Amoxicillin-clavulanic acid and Aztreonam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam combined with a beta-lactam or beta-lactamase inhibitor may give additive or synergistic activity against some Gram-negative organisms. This is a potentially beneficial effect, not a safety concern.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Aztreonam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Aztreonam belongs to Anti Bacterial.
Why it happens
Complementary binding to different penicillin-binding proteins, with clavulanate protecting against some beta-lactamases.
What to do
No safety monitoring is needed. Choose the regimen according to culture and susceptibility results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Aztreonam?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Aztreonam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam combined with a beta-lactam or beta-lactamase inhibitor may give additive or synergistic activity against some Gram-negative organisms. This is a potentially beneficial effect, not a safety concern.
How serious is the interaction between Amoxicillin-clavulanic acid and Aztreonam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No safety monitoring is needed. Choose the regimen according to culture and susceptibility results.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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