Drug interactions
Amikacin + Aztreonam
Severity: Minor
Amikacin and Aztreonam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam and amikacin are often combined deliberately for additive or synergistic activity against Pseudomonas and Enterobacterales. The pairing is generally beneficial, though aminoglycoside nephrotoxicity and ototoxicity still apply.
What this interaction means in plain words
Amikacin and Aztreonam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amikacin belongs to Anti Bacterial; Aztreonam belongs to Anti Bacterial.
Why it happens
Complementary antibacterial mechanisms: cell wall synthesis inhibition may enhance aminoglycoside uptake.
What to do
Use as clinically indicated; monitor serum creatinine and amikacin levels, and adjust the amikacin dose for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Aztreonam?
MediHelp rates the interaction as minor. Amikacin and Aztreonam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam and amikacin are often combined deliberately for additive or synergistic activity against Pseudomonas and Enterobacterales. The pairing is generally beneficial, though aminoglycoside nephrotoxicity and ototoxicity still apply.
How serious is the interaction between Amikacin and Aztreonam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use as clinically indicated; monitor serum creatinine and amikacin levels, and adjust the amikacin dose for renal function.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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