Drug interactions
Bacitracin + Cyclosporin
Severity: Major
Bacitracin and Cyclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic bacitracin is nephrotoxic, and combining it with cyclosporine adds to the risk of acute kidney injury. Parenteral bacitracin has largely been withdrawn for this reason.
What this interaction means in plain words
Bacitracin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Cyclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity: cyclosporine causes renal vasoconstriction while bacitracin causes direct tubular injury.
What to do
Avoid systemic bacitracin in patients taking cyclosporine and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and cyclosporine levels frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Bacitracin
- Bacitracin + Cidofovir Contraindicated
- Adefovir + Bacitracin Major
- Aldesleukin + Bacitracin Major
- Amikacin + Bacitracin Major
- Bacitracin + Carboplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Bacitracin with Cyclosporin?
MediHelp rates the interaction as major. Bacitracin and Cyclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin is nephrotoxic, and combining it with cyclosporine adds to the risk of acute kidney injury. Parenteral bacitracin has largely been withdrawn for this reason.
How serious is the interaction between Bacitracin and Cyclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic bacitracin in patients taking cyclosporine and choose a non-nephrotoxic alternative. If unavoidable, monitor serum creatinine and cyclosporine levels frequently.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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