Drug interactions
Bacitracin-neomycin-polymyxin + Vancomycin
Severity: Moderate
Bacitracin-neomycin-polymyxin and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic vancomycin can be nephrotoxic, and neomycin, polymyxin B and bacitracin may add to this if significantly absorbed from large wounds. With small-area topical use the risk is low.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity if the topical components are absorbed systemically.
What to do
Restrict the topical product to small areas and short durations. Monitor serum creatinine and vancomycin levels when wider use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Vancomycin?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic vancomycin can be nephrotoxic, and neomycin, polymyxin B and bacitracin may add to this if significantly absorbed from large wounds. With small-area topical use the risk is low.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Restrict the topical product to small areas and short durations. Monitor serum creatinine and vancomycin levels when wider use is needed.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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