Drug interactions
Baclofen + Chloral hydrate
Severity: Moderate
Baclofen and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic, and baclofen also depresses the central nervous system. Concurrent use can deepen sedation and may cause respiratory depression, especially in children, the elderly or those with renal impairment.
What this interaction means in plain words
Baclofen and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive CNS depression; the active metabolite trichloroethanol enhances GABA-A activity while baclofen acts at GABA-B receptors.
What to do
Use the lowest effective doses and monitor level of consciousness and respiratory status. Avoid other sedatives and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Baclofen with Chloral hydrate?
MediHelp rates the interaction as moderate. Baclofen and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic, and baclofen also depresses the central nervous system. Concurrent use can deepen sedation and may cause respiratory depression, especially in children, the elderly or those with renal impairment.
How serious is the interaction between Baclofen and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor level of consciousness and respiratory status. Avoid other sedatives and alcohol.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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