Drug interactions
Baclofen + Codeine
Severity: Moderate
Baclofen and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combined use can increase sedation, weakness and respiratory depression. Risk is higher in the elderly and with renal impairment.
What this interaction means in plain words
Baclofen and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via opioid receptors and GABA-B agonism.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate. Reduce baclofen dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Codeine?
MediHelp rates the interaction as moderate. Baclofen and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combined use can increase sedation, weakness and respiratory depression. Risk is higher in the elderly and with renal impairment.
How serious is the interaction between Baclofen and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Reduce baclofen dose in renal impairment.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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