Drug interactions
Baclofen + Cyclobenzaprine
Severity: Moderate
Baclofen and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are muscle relaxants that cause drowsiness, and cyclobenzaprine is structurally a tricyclic with anticholinergic effects. Combined use may increase sedation, dizziness and confusion, especially in older adults.
What this interaction means in plain words
Baclofen and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from two centrally acting muscle relaxants, with anticholinergic effects from cyclobenzaprine.
What to do
Avoid concurrent use of two muscle relaxants where possible, and in older adults prefer a single agent. If combined, use low doses and monitor sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Cyclobenzaprine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Baclofen with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Baclofen and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are muscle relaxants that cause drowsiness, and cyclobenzaprine is structurally a tricyclic with anticholinergic effects. Combined use may increase sedation, dizziness and confusion, especially in older adults.
How serious is the interaction between Baclofen and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two muscle relaxants where possible, and in older adults prefer a single agent. If combined, use low doses and monitor sedation and falls.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
