Drug interactions
Baclofen + Diphenoxylate
Severity: Moderate
Baclofen and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, especially above recommended doses, and it may add to baclofen sedation. Drowsiness, dizziness and impaired alertness are the typical results.
What this interaction means in plain words
Baclofen and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid receptor agonism and baclofen GABA-B agonism.
What to do
Keep diphenoxylate at labeled doses and monitor for oversedation. Advise avoiding alcohol and driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Baclofen with Diphenoxylate?
MediHelp rates the interaction as moderate. Baclofen and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal that can cause CNS depression, especially above recommended doses, and it may add to baclofen sedation. Drowsiness, dizziness and impaired alertness are the typical results.
How serious is the interaction between Baclofen and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep diphenoxylate at labeled doses and monitor for oversedation. Advise avoiding alcohol and driving until response is known.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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