Drug interactions
Baclofen + Methadone
Severity: Moderate
Baclofen and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen causes sedation and muscle weakness and can add to opioid-induced CNS and respiratory depression. The risk is greater at higher doses, in renal impairment, and in older patients.
What this interaction means in plain words
Baclofen and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-B agonism and mu-opioid effects.
What to do
Monitor sedation and respiratory function, start baclofen at a low dose and titrate slowly. Reduce doses if drowsiness or confusion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Methadone?
MediHelp rates the interaction as moderate. Baclofen and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen causes sedation and muscle weakness and can add to opioid-induced CNS and respiratory depression. The risk is greater at higher doses, in renal impairment, and in older patients.
How serious is the interaction between Baclofen and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, start baclofen at a low dose and titrate slowly. Reduce doses if drowsiness or confusion occurs.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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