Drug interactions
Baclofen + Morphine
Severity: Moderate
Baclofen and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can cause additive sedation, weakness and respiratory depression. Risk is greater with intrathecal baclofen, higher doses, older age or renal impairment.
What this interaction means in plain words
Baclofen and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression through opioid receptor activity and GABA-B agonism.
What to do
Use the lowest effective doses of each, titrate slowly, and monitor sedation and respiratory rate. Reduce doses in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Morphine?
MediHelp rates the interaction as moderate. Baclofen and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can cause additive sedation, weakness and respiratory depression. Risk is greater with intrathecal baclofen, higher doses, older age or renal impairment.
How serious is the interaction between Baclofen and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of each, titrate slowly, and monitor sedation and respiratory rate. Reduce doses in renal impairment.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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