Drug interactions
Baclofen + Zuranolone
Severity: Moderate
Baclofen and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes significant somnolence and impaired psychomotor performance, which baclofen can worsen. The combination may increase CNS depression and impair driving ability.
What this interaction means in plain words
Baclofen and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from the GABA-A positive modulator and GABA-B agonist.
What to do
Consider reducing the zuranolone dose if sedation occurs. Warn patients against driving or hazardous activities until the effects are known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Baclofen with Zuranolone?
MediHelp rates the interaction as moderate. Baclofen and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes significant somnolence and impaired psychomotor performance, which baclofen can worsen. The combination may increase CNS depression and impair driving ability.
How serious is the interaction between Baclofen and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose if sedation occurs. Warn patients against driving or hazardous activities until the effects are known.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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