Drug interactions
Baloxavir marboxil + Calcium carbonate
Severity: Moderate
Baloxavir marboxil and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baloxavir can chelate polyvalent cations such as calcium in the gut, which may reduce its absorption and lower antiviral exposure. Reduced exposure could compromise treatment of influenza.
What this interaction means in plain words
Baloxavir marboxil and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Chelation of baloxavir by calcium in the gastrointestinal tract reduces its oral absorption.
What to do
Avoid taking baloxavir together with calcium-containing antacids or supplements; if calcium is needed, give it at a separate time from baloxavir. Labeling advises avoiding co-administration with polyvalent cation products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Baloxavir marboxil
- Aluminum hydroxide + Baloxavir marboxil Moderate
- Baloxavir marboxil + Calcium Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Baloxavir marboxil + Ferrous fumarate Moderate
- Baloxavir marboxil + Ferrous gluconate Moderate
- Baloxavir marboxil + Ferrous sulfate Moderate
Frequently asked questions
Can I take Baloxavir marboxil with Calcium carbonate?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baloxavir can chelate polyvalent cations such as calcium in the gut, which may reduce its absorption and lower antiviral exposure. Reduced exposure could compromise treatment of influenza.
How serious is the interaction between Baloxavir marboxil and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking baloxavir together with calcium-containing antacids or supplements; if calcium is needed, give it at a separate time from baloxavir. Labeling advises avoiding co-administration with polyvalent cation products.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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