Drug interactions
Balsalazide + Naproxen
Severity: Minor
Balsalazide and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen is an organic acid that may compete with balsalazide metabolites for renal tubular secretion, with little expected clinical effect. NSAIDs can also provoke flares of inflammatory bowel disease and add renal risk.
What this interaction means in plain words
Balsalazide and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Naproxen belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular anionic secretion; this is largely theoretical.
What to do
No dose change is needed; monitor renal function and bowel symptoms if the combination is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Balsalazide
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Balsalazide with Naproxen?
MediHelp rates the interaction as minor. Balsalazide and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naproxen is an organic acid that may compete with balsalazide metabolites for renal tubular secretion, with little expected clinical effect. NSAIDs can also provoke flares of inflammatory bowel disease and add renal risk.
How serious is the interaction between Balsalazide and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor renal function and bowel symptoms if the combination is prolonged.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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