Drug interactions
Balsalazide + Tolmetin
Severity: Minor
Balsalazide and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin, an NSAID, may compete with mesalamine metabolites for renal tubular secretion. Both drugs can affect the kidney, so combined use adds a small nephrotoxic concern.
What this interaction means in plain words
Balsalazide and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Tolmetin belongs to Musculoskeletal.
Why it happens
Competition between organic anions for renal tubular secretion, plus possible additive renal effects.
What to do
Check renal function periodically during long-term combined use. Avoid the combination if kidney function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Balsalazide and Tolmetin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Balsalazide
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Balsalazide with Tolmetin?
MediHelp rates the interaction as minor. Balsalazide and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolmetin, an NSAID, may compete with mesalamine metabolites for renal tubular secretion. Both drugs can affect the kidney, so combined use adds a small nephrotoxic concern.
How serious is the interaction between Balsalazide and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function periodically during long-term combined use. Avoid the combination if kidney function is reduced.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
