Drug interactions
Baricitinib + Diflunisal
Severity: Moderate
Baricitinib and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may raise baricitinib exposure by blocking its renal elimination, which could increase the risk of dose-related adverse effects such as infection and cytopenias. Baricitinib labeling advises against use with strong OAT3 inhibitors.
What this interaction means in plain words
Baricitinib and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Diflunisal belongs to Musculoskeletal.
Why it happens
Inhibition of renal organic anion transporter 3 reduces tubular secretion of baricitinib.
What to do
If coadministration cannot be avoided, consider reducing the baricitinib dose according to labeling for OAT3 inhibitors, or choose another NSAID. Monitor for infection and blood count abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Diflunisal?
MediHelp rates the interaction as moderate. Baricitinib and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal may raise baricitinib exposure by blocking its renal elimination, which could increase the risk of dose-related adverse effects such as infection and cytopenias. Baricitinib labeling advises against use with strong OAT3 inhibitors.
How serious is the interaction between Baricitinib and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration cannot be avoided, consider reducing the baricitinib dose according to labeling for OAT3 inhibitors, or choose another NSAID. Monitor for infection and blood count abnormalities.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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