Drug interactions
Baricitinib + Irbesartan
Severity: Minor
Baricitinib and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is eliminated partly through renal OAT3 transport. Irbesartan has some OAT3 inhibitory activity in vitro, but a clinically significant increase in baricitinib exposure is not established.
What this interaction means in plain words
Baricitinib and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
Possible weak OAT3 inhibition reducing renal baricitinib clearance.
What to do
No dose change is routinely needed. Monitor for baricitinib adverse effects such as infection and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Baricitinib with Irbesartan?
MediHelp rates the interaction as minor. Baricitinib and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Baricitinib is eliminated partly through renal OAT3 transport. Irbesartan has some OAT3 inhibitory activity in vitro, but a clinically significant increase in baricitinib exposure is not established.
How serious is the interaction between Baricitinib and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for baricitinib adverse effects such as infection and cytopenias.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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