Drug interactions
Baricitinib + Oxaprozin
Severity: Moderate
Baricitinib and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may raise baricitinib exposure because baricitinib is cleared in part by renal tubular transport through OAT3. Higher levels could increase the risk of baricitinib adverse effects such as infection and cytopenias.
What this interaction means in plain words
Baricitinib and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of organic anion transporter 3 mediated renal secretion of baricitinib, although NSAIDs are weaker inhibitors than probenecid.
What to do
Monitor for infection and haematological abnormalities when oxaprozin is used with baricitinib. Reduce the baricitinib dose only if a strong OAT3 inhibitor is added as labeling advises, and otherwise keep NSAID use to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Oxaprozin?
MediHelp rates the interaction as moderate. Baricitinib and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may raise baricitinib exposure because baricitinib is cleared in part by renal tubular transport through OAT3. Higher levels could increase the risk of baricitinib adverse effects such as infection and cytopenias.
How serious is the interaction between Baricitinib and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and haematological abnormalities when oxaprozin is used with baricitinib. Reduce the baricitinib dose only if a strong OAT3 inhibitor is added as labeling advises, and otherwise keep NSAID use to the lowest effective dose.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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