Drug interactions
Basiliximab + Imlifidase
Severity: Moderate
Basiliximab and Imlifidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imlifidase cleaves IgG, so basiliximab given soon afterwards may be inactivated and lose its immunosuppressive effect. This could raise the risk of rejection.
What this interaction means in plain words
Basiliximab and Imlifidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Basiliximab belongs to Miscellaneous; Imlifidase belongs to Miscellaneous.
Why it happens
Imlifidase is an IgG-degrading enzyme that cleaves IgG-based antibodies including basiliximab.
What to do
Give basiliximab no sooner than 4 days after imlifidase, as stated in labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imlifidase
- Adalimumab + Imlifidase Moderate
- Alemtuzumab + Imlifidase Moderate
- Belatacept + Imlifidase Moderate
- Denosumab + Imlifidase Moderate
- Etanercept + Imlifidase Moderate
- Imlifidase + Rituximab Moderate
Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Imlifidase?
MediHelp rates the interaction as moderate. Basiliximab and Imlifidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imlifidase cleaves IgG, so basiliximab given soon afterwards may be inactivated and lose its immunosuppressive effect. This could raise the risk of rejection.
How serious is the interaction between Basiliximab and Imlifidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give basiliximab no sooner than 4 days after imlifidase, as stated in labeling.
What other medicines interact with Imlifidase?
MediHelp also lists interactions of Imlifidase with, for example, Adalimumab, Alemtuzumab, Belatacept. The full list is on the Imlifidase page.
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