Drug interactions
Denosumab + Imlifidase
Severity: Moderate
Denosumab and Imlifidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab is an IgG2 monoclonal antibody and is susceptible to cleavage by imlifidase. Given too soon after imlifidase, it may be inactivated and give less effective bone-resorption inhibition.
What this interaction means in plain words
Denosumab and Imlifidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Imlifidase belongs to Miscellaneous.
Why it happens
Imlifidase is an IgG-cleaving endopeptidase that enzymatically degrades therapeutic IgG antibodies such as denosumab.
What to do
Give denosumab at least 4 days after imlifidase, as stated in the product labeling. Time the dose to the usual schedule and avoid giving it early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imlifidase
- Adalimumab + Imlifidase Moderate
- Alemtuzumab + Imlifidase Moderate
- Basiliximab + Imlifidase Moderate
- Belatacept + Imlifidase Moderate
- Etanercept + Imlifidase Moderate
- Imlifidase + Rituximab Moderate
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Imlifidase?
MediHelp rates the interaction as moderate. Denosumab and Imlifidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab is an IgG2 monoclonal antibody and is susceptible to cleavage by imlifidase. Given too soon after imlifidase, it may be inactivated and give less effective bone-resorption inhibition.
How serious is the interaction between Denosumab and Imlifidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give denosumab at least 4 days after imlifidase, as stated in the product labeling. Time the dose to the usual schedule and avoid giving it early.
What other medicines interact with Imlifidase?
MediHelp also lists interactions of Imlifidase with, for example, Adalimumab, Alemtuzumab, Basiliximab. The full list is on the Imlifidase page.
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