Drug interactions
Imlifidase + Rituximab
Severity: Moderate
Imlifidase and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imlifidase cleaves IgG, so an IgG-based antibody given while imlifidase is still active can be degraded before it works. Rituximab given too soon after imlifidase may lose efficacy, for example in B-cell depletion for desensitization or antibody-mediated rejection.
What this interaction means in plain words
Imlifidase and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imlifidase belongs to Miscellaneous; Rituximab belongs to Musculoskeletal.
Why it happens
Imlifidase is an IgG-cleaving endopeptidase that enzymatically degrades therapeutic IgG antibodies such as rituximab.
What to do
Give rituximab at least 4 days after imlifidase, as stated in the product labeling. Plan the transplant immunosuppression schedule around this interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imlifidase
- Adalimumab + Imlifidase Moderate
- Alemtuzumab + Imlifidase Moderate
- Basiliximab + Imlifidase Moderate
- Belatacept + Imlifidase Moderate
- Denosumab + Imlifidase Moderate
- Etanercept + Imlifidase Moderate
Other interactions of Rituximab
Frequently asked questions
Can I take Imlifidase with Rituximab?
MediHelp rates the interaction as moderate. Imlifidase and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imlifidase cleaves IgG, so an IgG-based antibody given while imlifidase is still active can be degraded before it works. Rituximab given too soon after imlifidase may lose efficacy, for example in B-cell depletion for desensitization or antibody-mediated rejection.
How serious is the interaction between Imlifidase and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give rituximab at least 4 days after imlifidase, as stated in the product labeling. Plan the transplant immunosuppression schedule around this interval.
What other medicines interact with Imlifidase?
MediHelp also lists interactions of Imlifidase with, for example, Adalimumab, Alemtuzumab, Basiliximab. The full list is on the Imlifidase page.
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