Drug interactions
Bazedoxifene + Phenytoin
Severity: Moderate
Bazedoxifene and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may lower bazedoxifene exposure, weakening endometrial protection in combination with estrogens.
What this interaction means in plain words
Bazedoxifene and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces UGT enzymes, increasing bazedoxifene glucuronidation.
What to do
Monitor for abnormal vaginal bleeding or reduced effect. Consider alternative therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene
- Bazedoxifene + Carbamazepine Moderate
- Bazedoxifene + Phenobarbitone Moderate
- Bazedoxifene + Rifampicin Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Bazedoxifene with Phenytoin?
MediHelp rates the interaction as moderate. Bazedoxifene and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin may lower bazedoxifene exposure, weakening endometrial protection in combination with estrogens.
How serious is the interaction between Bazedoxifene and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abnormal vaginal bleeding or reduced effect. Consider alternative therapy if needed.
What other medicines interact with Bazedoxifene?
MediHelp also lists interactions of Bazedoxifene with, for example, Carbamazepine, Phenobarbitone, Rifampicin. The full list is on the Bazedoxifene page.
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