Drug interactions
Bazedoxifene + Phenobarbitone
Severity: Moderate
Bazedoxifene and Phenobarbitone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital may decrease bazedoxifene exposure, reducing endometrial protection with estrogen therapy.
What this interaction means in plain words
Bazedoxifene and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene belongs to Endocrine; Phenobarbitone belongs to Central Nervous System.
Why it happens
Phenobarbital induces UGT enzymes, increasing bazedoxifene glucuronidation.
What to do
Monitor for loss of efficacy, including abnormal uterine bleeding. Consider alternative therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene
- Bazedoxifene + Carbamazepine Moderate
- Bazedoxifene + Phenytoin Moderate
- Bazedoxifene + Rifampicin Moderate
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Bazedoxifene with Phenobarbitone?
MediHelp rates the interaction as moderate. Bazedoxifene and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital may decrease bazedoxifene exposure, reducing endometrial protection with estrogen therapy.
How serious is the interaction between Bazedoxifene and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy, including abnormal uterine bleeding. Consider alternative therapy if needed.
What other medicines interact with Bazedoxifene?
MediHelp also lists interactions of Bazedoxifene with, for example, Carbamazepine, Phenytoin, Rifampicin. The full list is on the Bazedoxifene page.
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