Drug interactions
Bazedoxifene + Rifampicin
Severity: Moderate
Bazedoxifene and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin may lower bazedoxifene concentrations and reduce its endometrial protective effect when combined with conjugated estrogens.
What this interaction means in plain words
Bazedoxifene and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces UGT enzymes, increasing glucuronidation of bazedoxifene.
What to do
Monitor for loss of efficacy, including abnormal vaginal bleeding. Consider an alternative to rifampicin or alternative therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene
- Bazedoxifene + Carbamazepine Moderate
- Bazedoxifene + Phenobarbitone Moderate
- Bazedoxifene + Phenytoin Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Bazedoxifene with Rifampicin?
MediHelp rates the interaction as moderate. Bazedoxifene and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin may lower bazedoxifene concentrations and reduce its endometrial protective effect when combined with conjugated estrogens.
How serious is the interaction between Bazedoxifene and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy, including abnormal vaginal bleeding. Consider an alternative to rifampicin or alternative therapy.
What other medicines interact with Bazedoxifene?
MediHelp also lists interactions of Bazedoxifene with, for example, Carbamazepine, Phenobarbitone, Phenytoin. The full list is on the Bazedoxifene page.
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